Overview

SCIENTIFIC SCORE
Moderately Effective
Based on 21 Researches
8
USERS' SCORE
Good
Based on 3 Reviews
8.3
Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
Colon Care BlendBifidobacterium lactis BL818, Lactobacillus acidophilus (SD-5221), Bifidobacterium lactis (SD-5674), Raw Whole Food Probiotic Blend: Bulgarian Yogurt (milk) Concentrate, ^Eastern European Wild Kefir Culture containing Bifidobacterium lactis, Bifidobacterium longum, Lactobacillus acidophilus, Lactobacillus brevis, Lactobacillus bulgaricus, Lactobacillus casei, Lactobacillus fermentum, Lactobacillus helveticus, Lactobacillus kefiranofaciens, Lactobacillus kefirgranum, Lactobacillus rhamnosus, Lactococcus lactis, Lactococcus cremoris, Streptococcus thermophilus, Lactobacillus kefir, Lactobacillus parakefir, Lactobacillus plantarum, Lactococcus lactis biovar diacetylactis, Leuconostoc lactis, Leuconostoc mesenteroides, Leuconostoc cremoris, Leuconostoc dextranicum, Kluyveromyces marxianus, Brettanomyces anomalus, Debaryomyces hansenii, Saccharomyces unisporus, Saccharomyces turicensis, Saccharomyces cerevisiae, Saccharomyces exiguus, Torulaspora delbrueckii
50 Billion CFU¹
+
Colon Transit Support Enzyme BlendAmylase, Protease, Lactase, Glucoamylase, alpha-Galactosidase, Lipase, Pectinase, Peptidase, Bromelain, Phytase, Hemicellulase, beta-Glucanase, Papain, Cellulase, Xylanase, Diastase, Invertase
50 mg
+
Eastern European Raw Fruit & Veggie BlendRed Bell Pepper (Fruit), Green Pea (Seed), Carrot (Root), Plum (Fruit), Cherry (Fruit), Strawberry (Fruit), Raspberry (Fruit)
45 mg
+

Top Medical Research Studies

9
Probiotic strain reduces cholesterol
We explored how Lactobacillus rhamnosus BFE5264 affects cholesterol levels using a mouse model on a high-cholesterol diet. This study revealed that this strain significantly reduced serum cholesterol levels while also altering the gut microbiome and increasing beneficial short-chain fatty acids. The findings suggest that L. rhamnosus could regulate cholesterol metabolism in the liver, showing effects similar to those of statin medications. These results highlight the potential of probiotics as a novel approach for managing cholesterol levels.
Read More
7
Probiotics may help lower cholesterol
We investigated the impact of two probiotic strains, Lactobacillus rhamnosus BFE5264 and Lactiplantibacillus plantarum NR74, on high cholesterol levels in a murine model. The results indicated that these probiotics help reduce cholesterol absorption in the intestines and support liver metabolism.

Specifically, L. rhamnosus was particularly effective in boosting cholesterol processing in the liver. However, as this study focused on animal models, more research is needed to confirm these findings in humans.

Overall, these probiotics show promise for managing diet-related hypercholesterolemia.
Read More
9
Lactobacillus rhamnosus shows cholesterol-lowering effects
We examined the potential of Lactobacillus rhamnosus and other strains to lower cholesterol levels. Through in vitro testing, we observed impressive cholesterol reduction rates, achieving up to 91% decrease after 120 hours. When we moved to in vivo studies using rats fed fermented milk, we noted reductions in overall cholesterol, LDL, and triglycerides, while also enhancing HDL levels. Importantly, these probiotic strains demonstrated safety and effectiveness in their role as natural options for managing high cholesterol.
Read More

Most Useful Reviews

9
Rapid recovery observed
1 people found this helpful
The effect exceeded my expectations. After taking a course of antibiotics in the hospital, I experienced diarrhoea. However, just two days after starting this probiotic, my stool returned to normal. I chose this product on my doctor’s recommendation, specifically Saccharomyces boulardi, although the cost is rather high. Nevertheless, I believe health is worth the investment.
Read More
7.5
Positive health results
I purchased this for intestinal health. Although the price is quite high, the effects have been good. I have noticed improvements in my digestive health.
Read More
6
Minimal effects noted
Good for the gut. As I have high bad cholesterol, I heard that probiotics might help lower it and benefit the intestines, so I decided to give it a try. However, my trial period was brief, and I did not notice any obvious effects. I experienced no adverse reactions from taking it, although I recommend drinking more water.
Read More

Medical Researches

SCIENTIFIC SCORE
Moderately Effective
Based on 21 Researches
8
  • All Researches
9
Lactobacillus reduces cholesterol and glucose
We investigated the effects of Lactobacillus rhamnosus on high cholesterol and blood sugar levels in diabetic rats.

By using yogurt fermented with this probiotic, we noticed significant reductions in blood glucose and an increase in healthy cholesterol levels.

Within just four days of consuming the yogurt, notable changes in liver and kidney enzymes were observed, alongside improvements in lipid profiles.

While promising, further research is needed to confirm these benefits in humans.
Read More
9
Probiotics can lower cholesterol effectively
We investigated the cholesterol-lowering effects of two specific probiotic strains, FM9 and Y57, using a high-fat diet model in male Wistar rats. Over 30 days, these strains demonstrated a significant ability to improve blood lipid profiles.

Notably, FM9 and Y57 reduced serum cholesterol levels by 9% and 8%, respectively, while also improving "good" HDL cholesterol levels more than the statin treatment.

These results suggest that probiotics like FM9 and Y57 may offer a natural alternative to conventional medications for managing cholesterol, with the potential for anti-obesity benefits too, though clinical trials are needed to confirm these effects in humans.
Read More
We explored how two specific probiotic strains, Lactobacillus johnsonni 3121 and Lactobacillus rhamnosus 86, impact high cholesterol conditions linked to obesity. In our study using obese mice on a high-fat diet, we observed that daily doses of these probiotics over 12 weeks led to significant improvements in cholesterol levels.

Notably, both strains reduced lipid accumulation and influenced the genes involved in fat cell development. Additionally, they helped restore the balance of gut bacteria affected by obesity. These findings suggest that these probiotics could be valuable in managing high cholesterol and obesity-related health issues.
Read More
9
Lactobacillus rhamnosus shows cholesterol-lowering effects
We examined the potential of Lactobacillus rhamnosus and other strains to lower cholesterol levels. Through in vitro testing, we observed impressive cholesterol reduction rates, achieving up to 91% decrease after 120 hours. When we moved to in vivo studies using rats fed fermented milk, we noted reductions in overall cholesterol, LDL, and triglycerides, while also enhancing HDL levels. Importantly, these probiotic strains demonstrated safety and effectiveness in their role as natural options for managing high cholesterol.
Read More
9
Probiotic strain reduces cholesterol
We explored how Lactobacillus rhamnosus BFE5264 affects cholesterol levels using a mouse model on a high-cholesterol diet. This study revealed that this strain significantly reduced serum cholesterol levels while also altering the gut microbiome and increasing beneficial short-chain fatty acids. The findings suggest that L. rhamnosus could regulate cholesterol metabolism in the liver, showing effects similar to those of statin medications. These results highlight the potential of probiotics as a novel approach for managing cholesterol levels.
Read More

User Reviews

USERS' SCORE
Good
Based on 3 Reviews
8.3
  • All Reviews
  • Positive Reviews
  • Negative Reviews
9
Rapid recovery observed
1 people found this helpful
The effect exceeded my expectations. After taking a course of antibiotics in the hospital, I experienced diarrhoea. However, just two days after starting this probiotic, my stool returned to normal. I chose this product on my doctor’s recommendation, specifically Saccharomyces boulardi, although the cost is rather high. Nevertheless, I believe health is worth the investment.
Read More
7.5
Positive health results
I purchased this for intestinal health. Although the price is quite high, the effects have been good. I have noticed improvements in my digestive health.
Read More
6
Minimal effects noted
Good for the gut. As I have high bad cholesterol, I heard that probiotics might help lower it and benefit the intestines, so I decided to give it a try. However, my trial period was brief, and I did not notice any obvious effects. I experienced no adverse reactions from taking it, although I recommend drinking more water.
Read More

Frequently Asked Questions

9
Rapid recovery observed
1 people found this helpful
The effect exceeded my expectations. After taking a course of antibiotics in the hospital, I experienced diarrhoea. However, just two days after starting this probiotic, my stool returned to normal. I chose this product on my doctor’s recommendation, specifically Saccharomyces boulardi, although the cost is rather high. Nevertheless, I believe health is worth the investment.
7.5
Positive health results
I purchased this for intestinal health. Although the price is quite high, the effects have been good. I have noticed improvements in my digestive health.
6
Minimal effects noted
Good for the gut. As I have high bad cholesterol, I heard that probiotics might help lower it and benefit the intestines, so I decided to give it a try. However, my trial period was brief, and I did not notice any obvious effects. I experienced no adverse reactions from taking it, although I recommend drinking more water.
9
Probiotic strain reduces cholesterol
We explored how Lactobacillus rhamnosus BFE5264 affects cholesterol levels using a mouse model on a high-cholesterol diet. This study revealed that this strain significantly reduced serum cholesterol levels while also altering the gut microbiome and increasing beneficial short-chain fatty acids. The findings suggest that L. rhamnosus could regulate cholesterol metabolism in the liver, showing effects similar to those of statin medications. These results highlight the potential of probiotics as a novel approach for managing cholesterol levels.
7
Potential cholesterol-lowering synbiotic
We explored how a new combination of Lactobacillus rhamnosus and xylo-oligosaccharides could help lower cholesterol levels. The study tested this synbiotic approach by simulating cholesterol-lowering effects in a lab setting.

Results suggested that it may work by down-regulating certain genes involved in cholesterol absorption and promoting a healthier gut microbiome. While promising, further research is needed to confirm its effectiveness in real-world conditions among people.
7
Probiotics may help lower cholesterol
We investigated the impact of two probiotic strains, Lactobacillus rhamnosus BFE5264 and Lactiplantibacillus plantarum NR74, on high cholesterol levels in a murine model. The results indicated that these probiotics help reduce cholesterol absorption in the intestines and support liver metabolism.

Specifically, L. rhamnosus was particularly effective in boosting cholesterol processing in the liver. However, as this study focused on animal models, more research is needed to confirm these findings in humans.

Overall, these probiotics show promise for managing diet-related hypercholesterolemia.
9
Probiotics can lower cholesterol effectively
We investigated the cholesterol-lowering effects of two specific probiotic strains, FM9 and Y57, using a high-fat diet model in male Wistar rats. Over 30 days, these strains demonstrated a significant ability to improve blood lipid profiles.

Notably, FM9 and Y57 reduced serum cholesterol levels by 9% and 8%, respectively, while also improving "good" HDL cholesterol levels more than the statin treatment.

These results suggest that probiotics like FM9 and Y57 may offer a natural alternative to conventional medications for managing cholesterol, with the potential for anti-obesity benefits too, though clinical trials are needed to confirm these effects in humans.

References

  1. Correia Gomes D, Meza Alvarado JE, Zamora Briseño JA, Cano Sarmiento C, Camacho Morales A, et al. Maternal Supplementation with GG Improves Glucose Tolerance and Modulates the Intestinal Microbiota of Offspring. Diseases. 2024;12. doi:10.3390/diseases12120312
  2. Dang L, Li D, Mu Q, Zhang N, Li C, et al. Youth-derived Lactobacillus rhamnosus with prebiotic xylo-oligosaccharide exhibits anti-hyperlipidemic effects as a novel synbiotic. Food Res Int. 2024;195:114976. doi:10.1016/j.foodres.2024.114976
  3. Papakonstantinou E, Zacharodimos N, Georgiopoulos G, Athanasaki C, Bothou DL, et al. Two-Month Consumption of Orange Juice Enriched with Vitamin D3 and Probiotics Decreases Body Weight, Insulin Resistance, Blood Lipids, and Arterial Blood Pressure in High-Cardiometabolic-Risk Patients on a Westernized Type Diet: Results from a Randomized Clinical Trial. Nutrients. 2024;16. doi:10.3390/nu16091331
  4. Negm El-Dein A, Ezzat A, Aly HF, Awad G, Farid M. Lactobacillus-fermented yogurt exerts hypoglycemic, hypocholesterolemic, and anti-inflammatory activities in STZ-induced diabetic Wistar rats. Nutr Res. 2022;108:22. doi:10.1016/j.nutres.2022.10.003
  5. Zafar H, Ain NU, Alshammari A, Alghamdi S, Raja H, et al. FM9 and Y57 Are as Effective as Statins at Improving Blood Lipid Profile in High Cholesterol, High-Fat Diet Model in Male Wistar Rats. Nutrients. 2022;14. doi:10.3390/nu14081654
  6. Yoon H, Lee Y, Kang HJ, Ju J, Ji Y, et al. Two putative probiotic strains improve diet-induced hypercholesterolemia through modulating intestinal cholesterol uptake and hepatic cholesterol efflux. J Appl Microbiol. 2022;132:562. doi:10.1111/jam.15181
  7. Daliri EB, Kim Y, Do Y, Chelliah R, Oh DH. In Vitro and In Vivo Cholesterol Reducing Ability and Safety of Probiotic Candidates Isolated from Korean Fermented Soya Beans. Probiotics Antimicrob Proteins. 2022;14:87. doi:10.1007/s12602-021-09798-0
  8. Lee CS, Park MH, Kim BK, Kim SH. Antiobesity Effect of Novel Probiotic Strains in a Mouse Model of High-Fat Diet-Induced Obesity. Probiotics Antimicrob Proteins. 2021;13:1054. doi:10.1007/s12602-021-09752-0
  9. El-Dein AN, Nour El-Deen AM, El-Shatoury EH, Awad GA, Ibrahim MK, et al. Assessment of exopolysaccharides, bacteriocins and in vitro and in vivo hypocholesterolemic potential of some Egyptian Lactobacillus spp. Int J Biol Macromol. 2021;173:66. doi:10.1016/j.ijbiomac.2021.01.107
  10. Das S, Mishra BK, Hati S. Techno-functional characterization of indigenous isolates from the traditional fermented foods of Meghalaya, India. Curr Res Food Sci. 2020;3:9. doi:10.1016/j.crfs.2020.01.002
  11. Romão da Silva LF, de Oliveira Y, de Souza EL, de Luna Freire MO, Braga VA, et al. Effects of probiotic therapy on cardio-metabolic parameters and autonomic modulation in hypertensive women: a randomized, triple-blind, placebo-controlled trial. Food Funct. 2020;11:7152. doi:10.1039/d0fo01661f
  12. Wa Y, Yin B, He Y, Xi W, Huang Y, et al. Effects of Single Probiotic- and Combined Probiotic-Fermented Milk on Lipid Metabolism in Hyperlipidemic Rats. Front Microbiol. 2019;10:1312. doi:10.3389/fmicb.2019.01312
  13. Yan Y, Zhang F, Chai Z, Liu M, Battino M, et al. Mixed fermentation of blueberry pomace with L. rhamnosus GG and L. plantarum-1: Enhance the active ingredient, antioxidant activity and health-promoting benefits. Food Chem Toxicol. 2019;131:110541. doi:10.1016/j.fct.2019.05.049
  14. Park S, Kang J, Choi S, Park H, Hwang E, et al. Cholesterol-lowering effect of Lactobacillus rhamnosus BFE5264 and its influence on the gut microbiome and propionate level in a murine model. PLoS One. 2018;13:e0203150. doi:10.1371/journal.pone.0203150
  15. Oh NS, Joung JY, Lee JY, Kim Y. Probiotic and anti-inflammatory potential of Lactobacillus rhamnosus 4B15 and Lactobacillus gasseri 4M13 isolated from infant feces. PLoS One. 2018;13:e0192021. doi:10.1371/journal.pone.0192021
  16. Roselli M, Devirgiliis C, Zinno P, Guantario B, Finamore A, et al. Impact of supplementation with a food-derived microbial community on obesity-associated inflammation and gut microbiota composition. Genes Nutr. 2017;12:25. doi:10.1186/s12263-017-0583-1
  17. Barache N, Belguesmia Y, Zeghbib W, Ladjouzi R, Ouarabi L, et al. Characterization and Biological In Vitro Screening of Probiotic Yeast Strains Isolated from Algerian Fruits. Probiotics Antimicrob Proteins. 2024. doi:10.1007/s12602-024-10389-y
  18. Selim S, Abdel-Megeid NS, Alhotan RA, Ebrahim A, Hussein E. Nutraceuticals vs. antibiotic growth promoters: differential impacts on performance, meat quality, blood lipids, cecal microbiota, and organ histomorphology of broiler chicken. Poult Sci. 2024;103:103971. doi:10.1016/j.psj.2024.103971
  19. Hosseini H, Abbasi A, Sabahi S, Akrami S, Yousefi-Avarvand A. Assessing the Potential Biological Activities of Postbiotics Derived from Saccharomyces cerevisiae: An In Vitro Study. Probiotics Antimicrob Proteins. 2024;16:1348. doi:10.1007/s12602-023-10117-y
  20. Wang Y, Han C, Cheng J, Wang Z, Liu L, et al. Fermented Cerasus humilis fruits protect against high-fat diet induced hyperlipidemia which is associated with alteration of gut microbiota. J Sci Food Agric. 2023;103:2554. doi:10.1002/jsfa.12377
  21. Razavi SA, Pourjafar M, Hajimohammadi A, Valizadeh R, Naserian AA, et al. Effects of dietary supplementation of bentonite and Saccharomyces cerevisiae cell wall on acute-phase protein and liver function in high-producing dairy cows during transition period. Trop Anim Health Prod. 2019;51:1225. doi:10.1007/s11250-019-01815-3
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